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Why is the source of heparin sodium from the pig small intestine rather than the artificial synthesis?
2022-11-07 Share:
  • 1. What kind of substance is heparin sodium?


    Heparin sodium, the relative mass of a molecule between 3000-30,000 Da, the average relative molecular mass is 15,000 Da, while the relative mass of a water molecule is 18 Da, that is, the relative molecular mass of heparin sodium is not like a small molecule like water, the difference is thousands of times; on another level, heparin sodium is also more complex structurally, belonging to a natural source of structural heterogeneity in the presence of multiple On the other hand, heparin sodium is structurally more complex and is a polymer of natural origin with multiple structural units and multiple modifications. To use an analogy, if a water molecule is a brick, then heparin sodium is a maze of tunnels with multiple organs, and there are no construction drawings for such tunnels.


    2. The difficulty of synthesis of heparin sodium


    Some people may wonder why heparin sodium is still extracted and refined from pig intestine now that technology is so advanced and can build space shuttles and aircraft carriers, and there are a lot of medical examination and treatment equipment and drugs in hospitals. Indeed, heparin sodium belongs to this difficult to synthesize molecules, the current level of science and technology is difficult to synthesize a large number of.


    3. The life cycle of porcine small intestine heparin sodium industry


    heparin sodium has been used in clinical applications for decades and is still the most effective drug to stop blood clotting. heparin sodium cannot be synthesized artificially in large quantities at present, and there is a profound scientific reason for scholars with senior scientific background to believe that there is no alternative to synthetic route for heparin sodium of porcine small intestine origin until at least 2050. The bulk of heparin drugs and their derivatives still rely on heparin sodium of porcine small intestine origin for a long or longer period of time. Therefore, the porcine small intestine heparin sodium industry is an evergreen industry and the market demand still persists in the long run.

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